再生医学实验室
主任兼首席研究员：杨志强博士. 克劳迪娅·比格蒂，DDS，硕士，博士
再生医学实验室, 成立于2022年11月, is part of the 足部医学院 at 德克萨斯大学里奥格兰德河谷分校. The mission of our lab is to foster interdisciplinary research in tissue engineering and regenerative medicine. We seek to optimize tissue healing and tissue homeostasis in patients with dysregulated inflammatory responses due to diabetes, 老化, 慢性神经病. 截至2017年, there are 425 million individuals affected with Type 1 and Type 2 Diabetes Mellitus (DM) worldwide, 包括34.200万美国成年人(1000万.占人口的5%). In the Lower Rio Grande Valley, community-wide screenings indicate a prevalence of DM in 30.7%的成年人. These patients suffer from impaired tissue healing and destructive inflammatory conditions. 在我们的实验室, our ultimate goal is to identify new potential targets for the development of therapeutic alternatives to prevent impaired tissue healing related to immune imbalance in diabetes and 老化. Our research projects are also developed in collaboration with other investigators and clinical experts from University of 德州里奥格兰德河谷 (德克萨斯州的哈林根, TX), University of 德州 at Houston Health Science Center (Houston, TX), 德克萨斯大学达拉斯分校, TX), 圣保罗大学(USP, 宝路, 圣保罗, 巴西), 和圣保罗州立大学（UNESP）, 阿拉萨图巴发生, 圣保罗, 巴西).
当前的项目
Targeting the HMGB1/CXCR4 pathway in diabetic osseointegration using a new implant surface approach.
Claudia Cristina Biguetti (Principal Investigator-金沙中国), Danieli Rodrigues (Principal Investigator -UTDallas), Hafizur Rahman （utrgv联合调查员）, 哈维尔·拉方丹（utrgv联合调查员）
Diabetic patients have higher incidence of fractures due to bone fragility caused by the diseases. 因此, clinical outcome of orthopedic procedures in diabetics is often inadequate with higher failure rates using titanium devices (10-15%) compared to non-diabetics (1-3%). 2018年，博士. 克劳迪娅·比格蒂和Dr. Gustavo Garlet (USP-巴西) described the role of a regenerative molecule called HMGB1 that participate in successful integration of titanium devices. 现在,博士. 比格蒂正在与布朗博士合作. Rodrigues (UTDallas) and their collaborators to develop a new surface approach to modulate these regenerative pathways using a titanium coating for fracture healing in diabetic patients.
Current tissue engineering strategies and clinical outcomes for diabetic foot ulcers.
Claudia Cristina Biguetti (Principal Investigator), 涩谷直宏（联合首席研究员）, 研究助理：Nathaniel Primous, 彼得·艾文, 阿方索雷耶斯
Diabetic foot ulcers (DFUs) comprise one of the major complications in DM and are a challenge in limb salvage. Unsuccessful healing of DFUs can ultimately result in amputation of lower extremity structures and increased risk of death. Tissue engineering strategies may have a positive impact in accelerating wound healing in these circumstances. Our goal in this study is to perform a scoping review on current tissue engineering strategies for treatment of DFU, followed by a systematic review and meta-analysis on at least three selected strategies. We expect that the results of this research will enhance the current knowledge of DFU treatment options and current challenges in Podiatry and Biomedical 研究.
Immunological Blood Biomarkers and Oral Microbiome in the Progression of Type II Diabetes: A Pilot Study in Mexican American Cohort from Rio Grande Valley.
Claudia Cristina Biguetti (Principal Investigator), Walid Fakhouri（合作研究员）, 克雷格·哈尼斯（联合调查员）. 研究 Assistants: 彼得·艾文, Olivia Mackey, Garret Edwards
Multifunctional Ionic Liquid Application for Treatment of Peri-implant Diseases
Claudia Cristina Biguetti (Co-Investigator 金沙中国), Danieli C. 罗德里格斯（首席研究员UTDallas）
在这项研究中. Biguetti’s Lab is collaborating with UTDallas in developing a multifunctional coating for treatment of inflammatory destructive bone disease that leads to implant loss.
目前的研究支持
- 金沙中国 教师 Seed Grant (Intramural 研究 Funding).
- UL1 – Cooperative Agreement - Center for Clinical & Translational Sciences, 金沙中国al Center for Advancing Translational Sciences, NIH
- 金沙中国al Institutes of Health, 金沙中国al Institute of Dental & 颅面研究
- UT系统-新星
